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Library GENERAL HEALTH Technical Bulletin of L- Sulforaphane Antioxidant: Sigma Technical Service Fahey, et al, "Broccoli Sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens", Proc. Natl. Acad. Sci. USA, Vol.94,pp.10367-10372, September 1997, Medical Sciences. Shapiro, Theresa A; Fahey, Jed W.: Wade. Kristina L.;Stephenson, Katherine K,; Talalay , Paul;" Chemoprotective glucosinolates and isothiocyanates of Broccoli Sprouts; metabolism and excretion in humans". Cancer Epidemiology, Biomarkers & Prevention, Vol. 10,501-508. May 2001. Prochaska et al," Rapid detections of inducers of enzymes that protect against carcinogens"; Proc. Natl. Acad. Sci. USA Vol. 89 pp 2394-2398 March 1992 Medical Sciences. Zjang, et al, " Anticarcinogenic activities of sulforaphane and structurally related synthetic morbornyl isothiocyanates"; Proc. Natil. Acad. Sci. USA Vol 89,pp 2399-2403 March 1992 Medical Sciences Fahey, Dr. Jed ,"The Safety of Glucoraphanin- (4-methylsulfinsylbutyl glucosinolate) and its metabolites. Institute of Food Research "Effects of food borne glucosinolates on human health (EFGLU)" Lampe,Johanna W,: Peterson, Sabrina;"Brassica, Biotransformantion and cancer risk: Genetic Polymorphism Alter the Preventive Effects of Cruciferous Vegetables" Choi, Sunga; Singh, Shivendra V.; Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable- derived cancer chemopreventive agent" Keck PhD, Anna- Sigrid; Finley PhD, John W,; Cruciferous Vegetables:Cancer Protective Mechanisms of Glucosinolate Hydrolysis Products and Selenium" Petri, Niclas; et al " Absorption/ Metabolism of Sulforaphane and Quercetin, and Regualtion of Phase II enzymes, In Human Jejunum in Vivo" Fowke, Jay H. et al; "Urinary Isothiocyanate Excretion, Brassica Consumption, and Gene Polymorphisms among women living in Shanghai, China".
DETOXIFICATION "Phytonutrients and Detoxification" "Antioxidant Functions of Sulforaphane: a Potent Inducer of Phase II Detoxification Enzymes" THE EYES "Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice" "Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulfroaphane" "Introduction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage."
THE BLADDER "The role of c-Jun in the AP-1 activation by naturally occurring isothiocyanates." "Broccoli compounds slow bladder cancer growth in lab." "Broccoli may help beat bladder cancer" "Dietary Isothiocyanates Inhibit the Growth of Human Bladder Carcinoma Cells" The Breast " Mechanism of Action and Antiproliferative Properties of Brassica oleracea juice in Human Breast Cancer Cell Lines" "Sulforaphane inhibits Human MCF-7 Cancer Cell Miotic Progerssion and Tubulin Polymerization." " Sulforaphane a naturally occuring mammary carcinoma mitotic inhibitor which disrupts polymerization" " Urinary Isothiocyanate Excretion, Brassica Consumption , and Gene Polymorphisms among women living in Shanghai , China." " Vegetable compound stops breast cancer cell growth" " Sulforaphane Inhibits Human MCF Mammary Cancer Cell Miotic Progression and TubulinPolymerization" Cardiovascular Inflammation "Dietary Approach to attenuate oxidative stress hypertension and inflammation in the cardiovascular system" Wu, et al, "Dietary approach to attenuate oxidative stress , hypertension, and inflammation in the cardiovascular systenm", PNAS May 4, 2004 Vol. 101, no.18
The Colon "Effects of Brassica Vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo" " Can dietary phase II Enzyme inducers ameliorate diseases with an underlying chronic inflammatory component to them" " Chemoprevention of colonic aberrant crypt foci in Fischer rats by sulforaphane and phenethyl isothiocyanates" " Glucuronidation as a Mechanism of Intrinsic Drug Resistance in Human Colon Cancer" Bonnesen, C., I. M. Eggleston, et al. (2001). "Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines." Detoxification " Phytonutrients and Detoxification" "Antioxidant functions of Sulforaphane a Potent Inducer of Phase II Detoxification Enzymes" Eyes "Sulforaphane Induces Thioredoxin through the antioxidant responsive element and attemuates retinal light damage in mice" "Powerful and prolonged protection of human retinal pigment epithelial cells keratinocytes and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforphane" Induction of phase 2 genes by sulforaphane protects retinal pigment epithilial cells against photooxidative damage" " Antioxidants found in broccoli and broccoli sprouts protects eyes form light damage " The Fetal Determinants " Dietary approachs to positively influence fetal determinants of adult health" Paolini, et al, "Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming and DNA damaging activities by glucorahanin he bio precursor of the chemoprotective agent sulforaphane found in broccoli", Carcinogenesis vol.25 no.1 pp61-67,2004 Joint Inflammation "Phytochemicals May Protect Cartilage Prevent Pain In Joints" "Broccoli compounds may protect joing health" Lung Cancer " Dietary Intake of Isothiocyanates:Evidence of a Joint Effect with Glutathione S- Transerase Polymorphisms in Lung Cancer Risk" " Combined Natural Source Inhibitors in Skin Cancer Prevention" " Effects of cruciferous vegetables on lung cancer in patients stratified by genetic status:a mendelian randomisation approach" Pancreatic "The dietay isothiocyanate sulforaphane targets pathways of apoptosis cell cycle arrest and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice" Prostate "Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention" " Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest" " Potent Induction of Phase 2 Enzymes in Human Prostate Cells by Sulforaphane" "Lifestyle, diet may halt prostate cancer progression" "Sulforaphane and it metabolite mediate growth arrest and apaptosis in human prostate cancer cells" Brooks, J. D. and V. Paton (1999). "Potent induction of carcinogen defence enzymes with sulforaphane, a putative prostate cancer chemopreventive agent." Prostate Cancer Prostatic Dis 2(S3): S8. Brooks, J. D., V. G. Paton, et al. (2001). "Potent induction of phase 2 enzymes in human prostate cells by sulforaphane." Cancer Epidemiol Biomarkers Prev 10(9): 949-54. Brooks, J. D., and S. B. Jones (2006). “Modest induction of phase 2 enzyme activity in the F-344 rat prostate.” BMC Cancer2006, 6:62. Chiao, J. W., F. L. Chung, et al. (2002). "Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells." Int J Oncol 20(3): 631-6. Chiao, et al, "Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells", International Journal of Oncology24: 187-192,2004. Wang, et al, "Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention," International Journal of Oncology 20: 631-636,2002 Chiao et al, " Ingestion of an isothiocyanante metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apaptosis and cell cycle arrest", Carcinogenesis vol. 25 no.8 pp 1403-1408 2004.
Skin "Protection against UV light induced skin carinogenesis in SKH-1 high risk mice by sulforaphane-containing broccoli sprout extracts" " Combined Natural Source Inhibiters in Skin Cancer Prevention" Gao and Talalay, " Induction of phase 2 genes by sulforaphane protects retinal pigament epithelial cells against photooxidative damage", PNAS, July 13,2004, Vol 101,no.28
Stomach Sulforaphane inhibits extacellular intracellular and antibiotic resistant strains of helicobacter pylori and prevents benzopyrene-induced stomach tumors"
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